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Heterosynaptic eLTD happens at synapses adjacent to the stimulated synapses. By way of example, stimulation of Schaffer collaterals in hippocampal CA1 results in a persistent lower in GABAergic inhibition of CA1 pyramidal neurons (106). The mechanism of eLTD at hippocampal inhibitory synapses seems to involve inhibition of adenylyl cyclase as well

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